Scientists studying Renaissance-era art have found tiny traces of DNA on objects tied to Leonardo da Vinci. This was done using a new method called arteomics, which investigates biological traces on historic items. The researchers swabbed the red chalk drawing "Holy Child," possibly by da Vinci, and letters from his relatives. Some DNA matched genetic groups from Tuscany, where da Vinci was born. They also found DNA from sweet orange trees, linking to Renaissance Medici gardens. While some DNA might come from da Vinci himself, experts say proof is not certain. Identifying DNA of da Vinci is tough because he left no direct descendants and his remains were scattered. To avoid contamination, only female scientists collected samples. The team used gentle swabs to take skin flakes, microbes, and pollen from artefacts without damage. Most DNA came from bacteria and plants, with some from humans. Plant DNA helped show where and how items were made or stored. Researchers warned that many people handled these artefacts over centuries, so modern DNA is mixed in. They stressed more studies are needed to confirm links to da Vinci and understand the artefacts' history better.